DS stylus is tiny; I use my pocket PC's one. As per the majority, I'm right-handed.
I hold the DS stylus in a disorderly way since it's too small for my big paws. xD
My PC one I can hold like a relatively short pencil, but again even that's not particularly good.
Personally I'm not a fan of touch screens; but I only play Pokemon and Advance Wars games anyway, both of which don't require the stylus.