The anime is considered good because it's one of the few animes that's a breath of fresh air from the typical moeblob anime we've been getting for years, which caused a lot of western viewers to grow a distaste towards modern anime (until they go back to making anime more akin to the ones from the 90's and early 2000's).
The story revolves around the Joestar family throughout their generations, beginning in the late 1800's, as they battle vampires that were formed by an Aztec mask. Later on, the series introduces stands, which are like Personas from the game series of the same name.