I went from Microsoft Paint and Mouse (Yes, I know) to Paint and Intuos Wacom Tablet, and then to Paint Tool SAI and an Intuos Wacom Tablet.
Very happy to work with a stylus and layers. What I don't like is that sometimes either the tablet (or the software?) bugs out, and my stylus goes into a different "mode" in which the drawing becomes laggy, the button on the stylus which I set for the Eyedropper tool ceases to work and transfers over to holding the stylus on the tablet for a few seconds instead, tried updating to no avail.