I'll do the same thing I do every time I play a new game for the first time - I'll catch pretty much everything, use all of them at least long enough to evolve them, rearrange them however seems to make sense at the moment, and end up beating the E4 with whatever team I decide on when I get there.
It's not until I've gone through the game at least once that I even consider using a fixed team from beginning to end, and even then, I usually don't.
That said, there are a few that I'm particularly looking forward to - Breloom, Shiftry, Surskit, Electrike, Absol... even Feebas.