I'd be down for it, if the execution is done right. Detective Pikachu gave me my dream of seeing Pokemon in live action, and I loved it. I wouldn't mind another, even if it's the worst thing ever. I personally wasn't bothered by the realistic looking CG Pokemon, but if they do another one, you know they can always experiment with other types of CGI styles. I highly doubt if we get something that is different from Detective Pikachu, they'd use the Detective Pikachu CGI. I'd imagine different live action Pokemon movies would try different CGI models, and it'd be cool to see.
Like, maybe they could do what they did with the virtual post malone concert, and use that cgi in a movie. As long as it isn't that awful Robot Chicken style cgi from the Mewtwo movie, I will take any style, any day.